Inappropriate prescription of allopurinol in a teaching hospital
Athisakul, S.; Wangkaew, S.; Louthrenoo, W.
Journal of the Medical Association of Thailand 90(5): 889-894
2007
ISSN/ISBN: 0125-2208 PMID: 17596042 Document Number: 2862
Background. Allopurinol is a drug that is widely used to treat hyperuricemia, but it is often prescribed inappropriately.Objective: The authors conducted a study to look for the appropriate allopurinol prescription and diagnosis of gout in the out-patient clinics at a university hospital.Material and Method. One hundred and forty-five patients who were newly prescribed allopurinol (128 males and 17 females, mean +/- SD age of 58.5 +/- 14.1 years) were enrolled in this study.Result: Only 77 (53.1%) received allopurinol with appropriate indications. Thirty-eight patients (26.2%) did not have allopurinol dose adjustment according to the patients' creatinine clearance. Among 131 patients, prescribed allopurinol for the diagnosis of gout, only 55 (42.0%) were diagnosed in accordance with the American Rheumatism Association criteria.Conclusion: Inappropriate use of allopurinol (both the indication andprescribed dosage) and inappropriate diagnosis of gout are major problems even in a large teaching hospital. An educational campaign program is warranted for achieving appropriate diagnosis of gout, and eliminating the inappropriate use of allopurinol.
Document emailed within 1 workday
