The efficacy of combined low dose of Allopurinol and benzbromarone compared to standard dose of Allopurinol in hyperuricemia
Akkasilpa, S.; Osiri, M.; Deesomchok, U.; Avihingsanon, Y.
Journal of the Medical Association of Thailand 87(9): 1087-1091
2004
ISSN/ISBN: 0125-2208 PMID: 15516011 Document Number: 2555
Objective : To compare the efficacy of combined low dose of hypouricemic drugs (Allopurinol 100 mg and benzbromarone 20 mg; Allomaron(R)) and standard dose 300 mg of allopurinol in hyperuricemia. Material and Method : A prospective, open study of 94 hyperuricemic patients was done at King Chulalongkorn Memorial Hospital. Each group of 47 patients was given a combined low dose of hypouricemic drugs (Allopurinol 100 mg and benzbromarone 20 mg; Allomaron) and a standard dose 300 mg of allopurinol. Serum uric acid was measured before and 4 weeks after receiving the drugs. The efficacy was measured from the difference of the level of serum uric acid before and after receiving the drugs. Results : The patients receiving the combined low dose of hypouricemic drugs and standard dose of allopurinol showed a mean reduction of serum uric acid of 2.5 +/- 3.4 mg/dl and 4.1 +/- 2.7 mg/dl consecutively. There was a statistically significant difference between the 2 groups (P = 0.010). Conclusion : This study demonstrates that the efficacy of standard dose 300 mg of allopurinol is superior to a combined low dose of allopurinol and benzbromarone in lowering the level of serum uric acid level.
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