Structural genes of coagulation factors VIi and X located on 13q34
Gilgenkrantz, S.; Briquel, M.E.; André, E.; Alexandre, P.; Jalbert, P.; Le Marec, B.; Pouzol, P.; Pommereuil, M.
Annales de Genetique 29(1): 32-35
1986
ISSN/ISBN: 0003-3995 PMID: 3487272 Document Number: 283834
From 7 cases of abnormalities involving chromosome 13, the structural gene(s) coding for coagulation factors VII and X were located in the region 13q34-13qter. Gene-dosage effects for these coagulation factors seem to act in both directions, causing a decrease when there is monosomy of segment 13q34, but also, as has not been demonstrated before, an increase when there is trisomy of this same segment.