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Role of calmodulin in the contractile function of the myocardium

Laptev, B.I.; Afanas'ev, S.A.; Prokop'eva, V.D.; Antoshkin, L.V.; Larionov, N.P.

Biulleten' Eksperimental'noi Biologii i Meditsiny 102(10): 389-390

1986

ISSN/ISBN: 0365-9615
PMID: 2876734
Document Number: 283438
The effect of phenothiazines-trifluoroperazine frenolone, majeptile and aminazine on contractility of papillar muscle of Wistar male rats associated with short-term Ca-concentration increase up to 4 mM has been studied. There has been found the parameter-relaxation index-the change of which under the effect of phenothiazines (10(-5) M in all the cases) made use of significantly correlates with the constants, which reflect the similarity of given agents with calmodulin.

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