Role of sialic acid loss in the myocardium in depressing the contractile function of the heart muscle during stress
Meerson, F.Z.; Saulia, A.I.; Gudumak, V.S.
Voprosy Meditsinskoi Khimii 31(2): 118-120
1985
ISSN/ISBN: 0042-8809 PMID: 3873749 Document Number: 250867
Under conditions of stress a time-dependent decrease in content of sialic acids was found in adult rats; within 9 hrs of the animal immobilization the sialic acid content was decreased by 40% as compared with controls. At the same time, activities of trypsin and LDHI were increased in blood serum. The data obtained suggest that activation of proteases occurring during the stress led to increased hydrolysis of base components of glycocalyx and to impairment of the cardiomyocyte sarcolemma. These phenomena appear to be responsible for the post-stress deterioration of heart muscle contractile functions.