Effect of exposure to green coffee dust extract on airway reactivity
Zuskin, E.; Dreshaj, I.; Jakupi, M.; Haxhiu, M.A.
Arhiv Za Higijenu Rada i Toksikologiju 37(2): 205-216
1986
ISSN/ISBN: 0004-1254 PMID: 3592993 Document Number: 282273
An experiment study on the effect of exposure to green coffee dust water-extract on airway responses to bronchoconstrictive drugs was carried out in eleven anaesthetized mongrel dogs. Inhalation of green coffee dust extract caused an increase in respiratory frequency (FR), minute volume (MV), lung resistance (RL) and dynamic elastance (Edyn), and a slight decrease in tidal volume (VT). Changes were greater in comparison to changes following saline inhalation, although the differences were not statistically significant (P > 0.05). Inhalation of green coffee dust extract did not change significantly the sensitivity of bronchial system to aerosolized acetylcholine (ACh). Responses to Ach following pretreatment with saline or green coffee dust extract were similar in all respiratory parameters. The findings with pure green coffee dust water-extract suggest that bronchospasm in coffee workers is not due to the pharmacological activity of the water soluble agent in the dust, or due to increased bronchial reactivity.