Inhibition of cephalosporinase of enterobacteria by ceftriaxone
Péchinot, A.; Duez, J.M.; Nordmann, P.; Kazmierczak, A.; Labia, R.
Pathologie-Biologie 34(5): 399-403
1986
ISSN/ISBN: 0369-8114 PMID: 3534712 Document Number: 281868
Resistance of ceftriaxone, cefotaxime and cefmenoxime to inactivation by the chromosomal constitutive cephalosporinases of Enterobacter cloacae P99, Morganella morganii GN 1510 and Serratia liquefaciens 132 was determined using high performance liquid chromatography. The inhibitory properties of ceftriaxone against the same cephalosporinases were studied by determining the residual amount of cephalothin used as the substrate. With a 1:50 cephalosporinase-cephalosporin ratio, ceftriaxone was less resistant to hydrolysis than cefotaxime of cefmenoxime but showed stronger inhibitory properties.