Pharmacokinetics of a water-soluble antioxidant from the class of 3-hydroxypyridines
Zherdev, V.P.; Sariev, A.K.; Dvorianinov, A.A.; Voronina, T.A.; Smirnov, L.D.
Biulleten' Eksperimental'noi Biologii i Meditsiny 101(3): 325-327
1986
ISSN/ISBN: 0365-9615 PMID: 3955219 Document Number: 280987
The study of pharmacokinetics of water-soluble 2-ethyl-6-methyl-3-hydroxypyridine salt (EM-3-HP) in rats has shown this substance to be quickly absorbed from the abdominal cavity of animals. Its maximal concentrations in the plasma, brain and liver were determined 2-3 hours later, with the following monoexponential decrease in EM-3-HP level with the elimination half-life of 2-6 hours observed. Considerable EM-3-HP tropism to membranes of endoplasmic reticulum in the liver and brain cells is suggested to cause its membranomodulatory effect and to facilitate its pharmacological activity.