Comparative characteristics of voluntary and semivoluntary methods of the alcoholization of rats
Nuzhnyĭ, V.P.; Abdrashitov, A.K.; Listvina, V.P.; Uspenskiĭ, A.E.
Farmakologiia i Toksikologiia 49(1): 96-100
1986
ISSN/ISBN: 0014-8318 PMID: 3948996 Document Number: 279627
Water and ethanol consumption, blood and urine ethanol concentrations were measured in male rats aged 1.5 to 8 months. The animals had ethanol solutions (5-25%) and water as alternate fluid (two-bottle choice) or a 10% ethanol solution as a sole water source. In both cases, the rats did not exceed 7 g/kg of ethanol consumption per day. From 10 a.m. to 16 p.m. the blood ethanol concentration was no more than 0.1 g/l. Ethanol excretion with urine did not go beyond 0.1% of the daily dose. Ethanol consumption was increased by 1-2 g/kg a day if saccharin (0.125%) and sodium chloride (1%) were added to ethanol solution. In this case the withdrawal signs developed after ethanol consumption cessation.