Hereditary resistance to anthrax and sensitivity to the anthrax toxin in mice
Abalakin, V.A.; Cherkasskiĭ, B.L.
Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 5: 45-49
1986
ISSN/ISBN: 0372-9311 PMID: 3088874 Document Number: 278934
The degree of the hereditary susceptibility of mice to anthrax caused by noncapsular and capsule-forming Bacillus anthracis strains has been found to be directly related to the sensitivity of the animals to the edematogenic and immunosuppressing action of anthrax toxin. The genetic analysis indicates that resistance to anthrax is probably controlled by a dominant gene, not linked with histocompatibility complex H-2 and, probably, unrelated to the presence of hemolytic activity in mouse sera, determined by component C5 of the complement.