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Ofloxacin: therapeutic activity in experimental infections

Guerra, L.; Erani, E.; Xerri, L.

Chemioterapia International Journal of the Mediterranean Society of ChemoTherapy 5(6): 375-378

1986

ISSN/ISBN: 0392-906X
PMID: 3467874
Document Number: 275032
The therapeutic activity of ofloxacin, a new oral fluoroquinolone antibacterial agent, was tested in experimental infections in rodents. Its activity was compared with that of nalidixic acid, norfloxacin, amoxicillin and cotrimoxazole in Pseudomonas aeruginosa pyelonephritis in the rat, and with that of amikacin and cefotaxime in Proteus morganii thigh infections in mice. Ofloxacin proved to be more effective than reference drugs, even if parenterally administered, in reducing the bacterial count in muscle, kidney and urine.

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