Effects of tumor type and burden on carcass lipid depletion in mice
Hollander, D.M.; Ebert, E.C.; Roberts, A.I.; Devereux, D.F.
Surgery 100(2): 292-297
1986
ISSN/ISBN: 0039-6060 PMID: 3738756 Document Number: 274753
Nude mice were given by inoculation human malignant melanoma, human colon adenocarcinoma or murine sarcoma cells or were untreated controls. Body weights, tumour burdens and carcass lipid contents were measured. Carcass weights of melanoma-bearing mice were significantly lower than those of sarcoma-bearing mice, mice exposed to colon cancer antigens but without tumour growth or control mice. The degree of carcass lipid loss in melanoma-bearing mice (mean tumour burden 3.5% of total body weight; TBW) was almost 3 times that of sarcoma-bearing mice, which had more than twice the tumour burden (mean tumour burden 7.8% TBW). Exposure to colon cancer antigens without tumour growth resulted in almost no carcass lipid depletion compared with control mice.