Effects of Chansu injection on transplanting-tumor models S180 in mice and human colon cancer HT-29 in nude mice
Yang, Z.-h.; Liang, Y.-j.; Guo, J.-w.; Pan, J.-q.; Ding, Y.; Li, G.-n.
Zhonghua Wei Chang Wai Ke Za Zhi 8(2): 169-171
2005
ISSN/ISBN: 1671-0274 PMID: 16155834 Document Number: 593358
To study the antitumor effects of Chansu injection on transplanting- tumor of S(180 ) in mice and human colon cancer HT-29 in nude mice. Using transplanting- tumor models of S(180 ) in mice and human colon cancer HT-29 in nude mice,the tumor inhibitive ratio(IR) of Chansu injection was determined and apoptosis was microscopically observed. Compared with tumor-negative control groups, IR at different dosage of Chansu in models of S(180) and HT-29 was 19.1% - 38.2% and 9.5% - 15.8% respectively,there was a dose-dependent relationship in models of S ( 180) (P< 0.05) and HT- 29 (P> 0.05). The tumor growth was markedly inhibited by cyclophosphamide (CTX) in model of S( 180) with IR of 70.7% and in model of HT-29 with IR of 67.1%, compared with control groups, both P< 0.01; apoptosis induced by CTX was markedly observed by in microscope examination. No significant side effects were shown in the study group. Chansu injection can significantly inhibit tumor growth in model of S(180), but not in model of HT- 29. Different type of tumor has different drug-sensitivity.