Top Abstract Purchase Related
Home
>
Node
>
Subnode

Imaging and biodistribution of 111In-labeled anti-carcinoembryonic antigen monoclonal antibodies in nude mice bearing human colon cancer xenografts

Wu, H.

Zhonghua Zhong Liu Za Zhi 11(4): 254-256

1989

ISSN/ISBN: 0253-3766
PMID: 2625105
Document Number: 345906
Anti-CEA monoclonal antibody was labeled with 111In using DTPA cyclic anhydride. The radiochemical purity of the product was more than 99% and specific binding was 38%. Imaging and biodistribution of this radiopharmaceutical in nude mice bearing human colon cancer xenografts were investigated. The results showed that a clear image of tumor was obtained by gamma camera between 24 to 120 hrs, best in 72 hrs, after injection. A high uptake of 111In-labeled monoclonal antibodies in tumor tissue was also observed, although the radioactivity in liver was considerable.

Document emailed within 1 workday
Secure & encrypted payments

Buchsbaum, D.J.; Wahl, R.L.; Normolle, D.P.; Kaminski, M.S. 1992: Therapy with unlabeled and 131I-labeled pan-B-cell monoclonal antibodies in nude mice bearing Raji Burkitt's lymphoma xenografts Cancer Research 52(23): 6476-6481
Zimmer, A.M.; Kazikiewicz, J.M.; Rosen, S.T.; Spies, S.M. 1987: Pharmacokinetics of 99mTc(Sn)- and 131I-labeled anti-carcinoembryonic antigen monoclonal antibody fragments in nude mice Cancer Research 47(6): 1691-1694
Zhang, J.-y.; Feng, J.; Li, H.-m.; Li, X.-d.; Jia, H.-l. 2011: Comparison of the biodistribution of four contrast agents in nude mice bearing NCI-H358 human lung cancer and evaluation of their value in diagnostic imaging Zhonghua Zhong Liu Za Zhi 33(7): 504-507
Shirozu, G.; Yamana, H.; Fujii, T.; Rikitake, H.; To, U.; Irie, H.; Kakegawa, T. 1992: Radiolocalization of murine monoclonal antibody KIS-1F (ab')2 fragment in nude mice bearing human esophageal cancer xenografts: preliminary report Nihon Geka Gakkai Zasshi 93(12): 1515
Shi, X.B. 1990: Biodistribution and radioimmunoimaging of monoclonal antibody to human lung adenocarcinoma in tumor-bearing nude mice Zhonghua Zhong Liu Za Zhi 12(3): 179-182
Cui, H. 1990: Biodistribution, pharmacokinetics and imaging of 131I-labeled HMD4 human McAb in human ovarian carcinoma xenograft in nude mice Zhonghua Fu Chan Ke Za Zhi 25(2): 80
Ward, B.G.; Wallace, K. 1987: Localization of the monoclonal antibody HMFG2 after intravenous and intraperitoneal injection into nude mice bearing subcutaneous and intraperitoneal human ovarian cancer xenografts Cancer Research 47(17): 4714-4718
Buchsbaum, D.; Lloyd, R.; Juni, J.; Wollner, I.; Brubaker, P.; Hanna, D.; Spicker, J.; Burns, F.; Steplewski, Z.; Colcher, D. 1988: Localization and imaging of radiolabeled monoclonal antibodies against colorectal carcinoma in tumor-bearing nude mice Cancer Research 48(15): 4324-4333
Shi, X.B. 1989: Localization of human lung cancer xenografts in nude mice using monoclonal antibody Zhonghua Yi Xue Za Zhi 69(8): 443-446; 32
Boven, E.; van der Vijgh, W.J.; Nauta, M.M.; Schlüper, H.M.; Pinedo, H.M. 1985: Comparative activity and distribution studies of five platinum analogues in nude mice bearing human ovarian carcinoma xenografts Cancer Research 45(1): 86-90
Mount, P.F.; Sutton, V.R.; Li, W.; Burgess, J.; McKEnzie, I.F.; Pietersz, G.A.; Trapani, J.A. 1994: Chimeric (mouse/human) anti-colon cancer antibody c30.6 inhibits the growth of human colorectal cancer xenografts in scid/scid mice Cancer Research 54(23): 6160-6166
Sharkey, R.M.; Gold, D.V.; Aninipot, R.; Vagg, R.; Ballance, C.; Newman, E.S.; Ostella, F.; Hansen, H.J.; Goldenberg, D.M. 1990: Comparison of tumor targeting in nude mice by murine monoclonal antibodies directed against different human colorectal cancer antigens Cancer Research 50(3 Suppl): 828s-834s
Stoffel, A.; Neumaier, M.; Gaida, F.J.; Fenger, U.; Drzeniek, Z.; Haubeck, H.D.; Wagener, C. 1993: Monoclonal, anti-domain and anti-peptide antibodies assign the molecular weight 160,000 granulocyte membrane antigen of the CD66 cluster to a mRNA species encoded by the biliary glycoprotein gene, a member of the carcinoembryonic antigen gene family Journal of Immunology 150(11): 4978-4984
Goldenberg, D.M.; Goldenberg, H.; Sharkey, R.M.; Higginbotham-Ford, E.; Lee, R.E.; Swayne, L.C.; Burger, K.A.; Tsai, D.; Horowitz, J.A.; Hall, T.C. 1990: Clinical studies of cancer radioimmunodetection with carcinoembryonic antigen monoclonal antibody fragments labeled with 123i or 99mTc Cancer Research 50(3 Suppl): 909s-921s
Sun, W.; Jiang, Z.; Xiang, T.-X.; Tao, X.-H.; Huang, A.-L.; Wang, P.-L. 2009: Anti-tumor effect of eukaryotic expressing plasmid containing soluble tumor necrotic factor-related apoptosis inducing ligand combined with human angiostatin Kringle (1 - 3) genes on human gastric cancer xenografts in nude mice Zhonghua Yi Xue Za Zhi 89(12): 841-845
Sugiyama, Y.; Chen, F.A.; Takita, H.; Bankert, R.B. 1988: Selective growth inhibition of human lung cancer cell lines bearing a surface glycoprotein gp160 by 125I-labeled anti-gp160 monoclonal antibody Cancer Research 48(10): 2768-2773
Behr, T.M.; Becker, W.S.; Klein, M.W.; Bair, H.J.; Scheele, J.R.; Wolf, F.G. 1995: Diagnostic accuracy and tumor-targeting kinetics of complete versus fragmented 99mTc-labeled anti-carcinoembryonic antigen antibodies: an intraindividual comparison Cancer Research 55(23 Suppl): 5786s-5793s
Ahlström, H. 1991: Anatomy and permeability of tumour vessels. An experimental study in nude rats with the aim of increasing the uptake of monoclonal anti-CEA antibodies in human colonic cancer Acta Radiologica. Supplementum 375: 141-158
Juhl, H.; Sievers, M.; Baltzer, K.; Helmig, F.; Wolf, H.; Brenner, W.; Kalthoff, H. 1995: A monoclonal antibody-cobra venom factor conjugate increases the tumor-specific uptake of a 99mTc-labeled anti-carcinoembryonic antigen antibody by a two-step approach Cancer Research 55(23 Suppl): 5749s-5755s
Agius, M.A.; Geannopoulos, C.J.; Fairclough, R.H.; Richman, D.P. 1988: Monoclonal anti-idiotopic antibodies against myasthenia-inducing anti-acetylcholine receptor monoclonal antibodies. Preponderance of nonparatope-directed antibodies affecting antigen binding Journal of Immunology 140(1): 62-68