Clinical and hemodynamic effects of captopril in patients with chronic circulatory failure
Vakhliaev, V.D.; Pomerantsev, E.V.; Makolkin, V.I.; Iudichev, I.S.; Syrkin, A.L.
Kardiologiia 26(8): 67-70
1986
ISSN/ISBN: 0022-9040 PMID: 3531671 Document Number: 273371
The effect of a new drug, captopril, an inhibitor of the enzyme responsible for the conversion of angiotensin I to angiotensin II, were examined in 15 patients with chronic circulatory insufficiency in the presence of coronary heart disease. The efficiency of single doses and four-week courses of the drug was assessed. Captopril was shown to reduce significantly pulmonary arterial occlusion pressure and total peripheral resistance and increase the minute volume, thus improving left-ventricular function. Considering good tolerance of the drug, it can be recommended for the treatment of chronic circulatory insufficiency.