Ultrastructural and immunofluorescent studies of glomerulonephritis in chronic hog cholera
Cheville, N.F.; Mengeling, W.L.; Zinober, M.R.
Laboratory Investigation; a Journal of Technical Methods and Pathology 22(5): 458-467
1970
ISSN/ISBN: 0023-6837 PMID: 4911978 Document Number: 27329
Specific-pathogen-free pigs were inoculated at about three months of age with an isolate previously shown to produce chronic swine fever, and were killed between 20 and 126 days later, when they appeared to be in the terminal stage of the disease. The severity of the renal lesions varied directly with the survival time after inoculation. Detailed results of the examination of kidney tissue by light, immunofluorescent and electron microscopy are given (14 photomicrographs). They include a prominence of neutrophiles, renal arterial degeneration, and deposition of electron-dense material within the glomerular mesangium, the epithelial cell foot processes being affected in more advanced lesions.