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The anticoagulant properties of mast cell product, chondroitin sulphate E

Scully, M.F.; Ellis, V.; Seno, N.; Kakkar, V.V.

Biochemical and Biophysical Research Communications 137(1): 15-22

1986

ISSN/ISBN: 0006-291X
PMID: 3087353
Document Number: 273274
The anticoagulant potency in vitro of chondroitin sulphate E has been found to be similar to that of the heparinoids. In purified systems chondroitin sulphate E was shown to be principally an activator of heparin cofactor II. Maximum acceleration of heparin cofactor II:thrombin interaction was 185-fold (9.3 .times. 107 M-1 min-1), antithrombin III:thrombin interaction was 11-fold (4.16 .times. 106 M-1 min-1) and antithrombin III:factor Xa was 146-fold (3.86 .times. 106 M-1 min-1). Chondroitin sulphate E was observed to prolong the thrombin clotting time of fibrinogen in the absence of antithrombin III and heparin cofactor II. The effect appeared to be related to interference in thrombin:fibrinogen interaction rather than in fibrin monomer polymerization.

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