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Effects of arterial pH and HCO-3 concentration on HCO-3 secretion in the isolated blood-perfused dog pancreas

Iijima, F.; Yamagishi, F.; Iwatsuki, K.; Chiba, S.

Archives Internationales de Pharmacodynamie et de Therapie 279(2): 314-323

1986

ISSN/ISBN: 0003-9780
PMID: 3963941
Document Number: 273159
We examined the effects of plasma pH and plasma HCO-3 concentration on pancreatic HCO-3 secretion in resting state and in stimulated state by secretin, pancreozymin or dopamine, using the isolated blood-perfused dog pancreas. Secretin- or pancreozymin-induced HCO-3 secretion was sensitive to changes in both plasma pH and HCO-3 concentration. On the other hand, neither plasma pH nor plasma HCO-3 concentration affected dopamine-induced HCO-3 secretion and spontaneous HCO-3 secretion. These results suggest that secretin- or pancreozymin-induced pancreatic HCO-3 secretion is induced by the active H+-pump, but dopamine-induced or spontaneous pancreatic HCO-3 secretion may be caused by different mechanisms.

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