Some observations on the toxicosis of isometamidium chloride (samorin) in camels
Ali, B.H.; Hassan, T.
Veterinary and Human Toxicology 28(5): 424-426
1986
ISSN/ISBN: 0145-6296 PMID: 3776085 Document Number: 271559
Healthy camels were experimentally infected with Trypanosoma evansi and then treated with isometamidium chloride (Samorin) at single intravenous doses of 0.5 or 1.0 mg/kg. Five to 10 min after the drug administration, the camels at both dosages showed lacrimation, salivation, trembling, restlessness, frequent urination and defaecation, followed by diarrhoea. Moreover, the camels at the higher dose showed an unsteady gait for about an hour with hindleg weakness and walked backwards. The animals fell to the ground, laid on their sides, and bent their necks into an "S" shaped curve. Three hours after the drug administration all the animals stood up and remained quiet. The treatment increased the concentration of plasma ammonia and total protein. Two hours after treatment, the activity of plasma cholinesterase was reduced. the enzyme activity recovered 24 h after drug administration, but was still below the control value.