Pharmacodynamic and pharmacokinetic approaches to optimization of the use of digoxin in the subacute period of myocardial infarction in late middle-age and elderly patients
Iakovlev, S.V.; Glezer, M.G.; Kholodov, L.E.; Chistova, V.S.; Mikhaĭlov, A.A.
Kardiologiia 26(9): 92-95
1986
ISSN/ISBN: 0022-9040 PMID: 3784274 Document Number: 271429
The efficiency of digoxin in elderly and old patients with subacute myocardial infarction is dependent on the original disorders of left-ventricular systolic phase structure. Changes in systolic phase structural parameters in the presence of supporting digoxin therapy show correspondence to changes of these parameters in response to a single digoxin dose. Digoxin's positive inotropic effect was similar in patients with the sinus rhythm and those with atrial fibrillation. The positive inotropic action of digoxin is not associated with a negative chronotropic effect in patients with sinus rhythm and normal heart rate.