Repair of potentially lethal radiation damage in confluent and non-confluent cultures of human hybrid cells
Sun, C.; Redpath, J.L.; Colman, M.; Stanbridge, E.J.
International Journal of Radiation Biology and Related Studies in Physics Chemistry and Medicine 49(3): 395-402
1986
ISSN/ISBN: 0020-7616 PMID: 3485588 Document Number: 271153
The repair of potentially lethal damage (PLDR) in a gamma-irradiated human hybrid cell line (skin fibroblast X HeLa) and its tumourigenic segregant has been studied as a function of cell density at the time of irradiation and during the postirradiation repair period. The data show that PLDR occurs in both non-confluent and confluent cultures of both cell lines. Furthermore, there is evidence that the extent of PLDR is dependent on cell density and that cell-cell contact may be an important factor in this regard.