Cell cycle phase recovery from bleomycin-induced potentially lethal damage
Barranco, S.C.; Bolton, W.E.
Cancer Research 37(8 Pt 1): 2589-2591
1977
ISSN/ISBN: 0008-5472 PMID: 68809 Document Number: 111864
Mammalian cells treated during mitosis with the anticancer drug bleomycin cannot recover from potentially lethal damage. G1- and S-phase cells treated in a similar manner can recover. In synchronized G1- and S-phase cells, and in asynchronous and nondividing populations, the final survival values of recovered cells have always been found to be greater than 0.2. These data suggest that a certain fixed amount of recovery can occur, regardless of the degree of initial bleomycin-induced damage. The mechanism of this particular phenomenon is unknown.