Integration of laboratory and epidemiologic studies to evaluate genotoxic exposure in tool and die workers
Garry, V.F.; Jacobs, D.R.; Kreiger, R.A.; Nelson, R.L.; Loeppky, R.; Harkins, M.E.
Progress in Clinical and Biological Research 207: 183-193
1986
ISSN/ISBN: 0361-7742 PMID: 3960871 Document Number: 270542
In summary, the data presented here provides perspective on the analysis of cancer in a relatively small population of tool and die workers. Each part of the effort establishes evidence for or against the presence of a workplace carcinogenic effect. Overall, the weight of evidence leads to the hypothesis that cutting fluids are a likely candidate for observed increases in urinary system cancer and perhaps other sites. Because cutting fluids and a wide variety of metals are used together, the interaction of these entities need be considered in the overall process of carcinogenesis in the workplace.