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Endothelial surface ultrastructure following hypoxia and hyperoxia

Bylock, A.; Stenberg, B.; Risberg, B.

Artery 13(5): 286-306

1986

ISSN/ISBN: 0098-6127
PMID: 3741158
Document Number: 270098
Effects of hypoxia and hyperoxia on the ultrastructure of aortic endothelial cells were studied in rats. Rats were subjected to FIO2 0.05, 0.06 or 0.1 for various period times. Hypoxia was followed by nuclei protrusion, appearance of holes through the luminal membranes of individual cells. Some cells showed signs of partial of total desintegration. Hyperoxia (FIO2 = 1.0) were followed by slight morphological changes noteable after 8 hours but most pronounced after 24 hours. The present study corroborated previous studies in that both hypoxia and hyperoxia can alter endothelial integrity.

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