Top Abstract Purchase Related
Home
>
Node
>
Subnode

Age-related changes of iris stromal melanocytes in human eyes

Sugita, A.; Tanaka, T.; Yoshioka, H.

Japanese Journal of Ophthalmology 30(2): 174-179

1986

ISSN/ISBN: 0021-5155
PMID: 3761741
Document Number: 268665
Age-related changes of the melanocytes in the human iris stroma were studied by electron microscopy. The iris specimens were obtained during cataract surgery of patients aged from 70 to 84 years. The most characteristic age-related changes in the iris stromal melanocytes were formation of melanosome complexes in the cytoplasm. In addition, nuclear bodies were seen within the nucleus. The diameter of the nuclear bodies varied from 0.8 to 2.0 micron and they contained dense osmiophilic granules similar to melanin granules. Lipofuscin granules, which are known as an age-related marker of cardiac muscle cells and neurons, were not observed in the cytoplasm. The clinical significance of these age-related changes in the iris stromal melanocytes remains to be discussed in the future.

Document emailed within 1 workday
Secure & encrypted payments

Sugita, A.; Yoshioka, H. 1984: An electron microscopic study of the melanocytes in the iris stroma of infantile, juvenile and adult Japanese monkeys Nippon Ganka Gakkai Zasshi 88(2): 290-297
Volkov, V.V.; Chernousenko, V.N. 1975: Surgical removal of congenital coloboma of the iris in both eyes Oftalmologicheskii Zhurnal 30(7): 548-549
Yung, R.; Eiferman, R.A. 1992: Spontaneous iris stromal cyst: a case report and review of literature Annals of Ophthalmology 24(4): 139-142
Sugita, A. 1978: Scanning electron microscopic studies of the normal ocular tissues. 2. Scanning and transmission electron microscopic studies of the melanocytes in the iris stroma of Japanese monkey Nippon Ganka Gakkai Zasshi 82(11): 786-797
Santini, D.; Ceccarelli, C.; Leone, O.; Pasquinelli, G.; Piana, S.; Marabini, A.; Martinelli, G.N. 1995: Smooth muscle differentiation in normal human ovaries, ovarian stromal hyperplasia and ovarian granulosa-stromal cells tumors Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology Inc 8(1): 25-30
Wrześniok, D.; Oprzondek, M.; Hechmann, A.; Beberok, A.; Otreba, M.ł; Buszman, E. 2016: Effect of Paracetamol on Melanization Process in Human Epidermal Melanocytes Acta Poloniae Pharmaceutica 73(3): 653-658
Loir, B.; Pérez Sánchez, C.; Ghanem, G.; Lozano, J.A.; García-Borrón, J.C.; Jiménez-Cervantes, C. 1999: Expression of the MC1 receptor gene in normal and malignant human melanocytes. a semiquantitative RT-PCR study Cellular and Molecular Biology 45(7): 1083-1092
Aiyar, S. 1983: Attempts to infect experimentally immunosuppressed iris monkeys (Macaca iris) with Brugia malayi Southeast Asian Journal of Tropical Medicine and Public Health 14(4): 505-509
Otreba, M.ł; Wrześniok, D.; Beberok, A.; Rok, J.; Buszman, E. 2016: Fluphenazine and Perphenazine Impact on Melanogenesis and Antioxidant Enzymes Activity in Normal Human Melanocytes Acta Poloniae Pharmaceutica 73(4): 903-911
Sakuraba, M.; Yun, S.; Ichinohe, N.; Yonekura, H.; Shoumura, K. 1999: Lattice-like collagen fiber meshwork in the iris stroma of the cat: a possible mechanism to generate the tension directed towards the iris root which is required for pupillary dilatation in the sympathectomized eye Kaibogaku Zasshi. Journal of Anatomy 74(5): 577-586
Ekesten, B.; Torrång, I. 1995: Age-related changes in ocular distances in normal eyes of Samoyeds American Journal of Veterinary Research 56(1): 127-133
Beitner, H.; Wennersten, G. 1983: The immediate action of long-wave ultraviolet radiation (UVA) on suprabasal melanocytes in human skin: a transmission electron microscopical study Acta Dermato-Venereologica 63(4): 328-334
Zhuravleva, E.S.; Saburina, I.N.; Borzenok, S.A.; Doga, A.V.; Kosheleva, N.V.; Kachalina, G.F.; Magaramov, D.A.; Tonaeva, K.D. 2011: Experimental study of safety in application of the Iris Medical IQ 810 diode laser in clinical treatment of age-related macular degeneration Patologicheskaia Fiziologiia i Eksperimental'naia Terapiia 3: 16-20
Barvic, M.; Soukup, F. 1972: Use of the structure of the human iris in forensic genetics Sbornik Lekarsky 74(10): 289-296
Norgauer, J.; Dichmann, S.; Peters, F.; Mockenhaupt, M.; Schraufst tter, I.; Herouy, Y. 2003: Tumor necrosis factor alpha induces upregulation of CXC-chemokine receptor type Ii expression and magnifies the proliferative activity of CXC-chemokines in human melanocytes European Journal of Dermatology: Ejd 13(2): 124-129
Cussac, C.; Rapp, M.; Mounetou, E.; Madelmont, J.C.; Maurizis, J.C.; Godeneche, D.; Dupuy, J.M.; Sauzieres, J.; Baudry, J.P.; Veyre, A. 1994: Enhancement by O6-benzyl-N-acetylguanosine derivatives of chloroethylnitrosourea antitumor action in chloroethylnitrosourea-resistant human malignant melanocytes Journal of Pharmacology and Experimental Therapeutics 271(3): 1353-1358
Bobrova, E.V.; Petrov, A.V. 1978: Ultrastructure of the anterior layers and dilatator pupillae in the human iris Vestnik Oftalmologii 4: 41-45
Krasnov, M.M. 1975: Artificial crystalline lens fixed onto the iris outside the pupil (extrapupillary iris-lens) Vestnik Oftalmologii 4: 42-45
Medrano, E.E.; Im, S.; Yang, F.; Abdel-Malek, Z.A. 1995: Ultraviolet B light induces G1 arrest in human melanocytes by prolonged inhibition of retinoblastoma protein phosphorylation associated with long-term expression of the p21Waf-1/SDI-1/Cip-1 protein Cancer Research 55(18): 4047-4052
Herlyn, M.; Guerry, D.; Koprowski, H. 1985: Recombinant gamma-interferon induces changes in expression and shedding of antigens associated with normal human melanocytes, nevus cells, and primary and metastatic melanoma cells Journal of Immunology 134(6): 4226-4230