Attempts to infect experimentally immunosuppressed iris monkeys (Macaca iris) with Brugia malayi
Aiyar, S.
Southeast Asian Journal of Tropical Medicine and Public Health 14(4): 505-509
1983
ISSN/ISBN: 0125-1562 PMID: 6673128 Document Number: 201735
Iris monkeys resistant to repeated infections with B. malayi were subjected to immunosuppression by treatment with cortisone. Degree of immunosuppression was measured by: blood counts, lymphocyte transformation to mitogens and immunofluorescent antibody to microfilarial antigens. Attempts were made to infect such immunosuppressed animals with B. malayi. No microfilariae were detected in the blood of any of the M. irus monkeys during the 6 mo. study. There was a sharp drop in the percentages of lymphocytes, but a rise in neutrophil counts during the 1st wk of cortisone administration. Treatment with cortisone did not alter the antibody titers. The significance of this line of approach in the understanding of filarial resistance is discussed.