Immunological study of the T- and B-lymphocytes in normal cows and in chronic lympholeukemia
Surovas, V.M.; Tamoshiunas, V.I.
Tsitologiia 28(4): 437-442
1986
ISSN/ISBN: 0041-3771 PMID: 3487146 Document Number: 268104
T- and B-lymphocyte populations from lymphoid organs and tissue of normal cattle and cattle with chronic lymphocytic leukaemia (CLL) were studied. Comparative studies of surface properties, quantitative parameters and heterogeneity of main T- and B-cell populations were performed. It must be noted that proliferation of B-lymphocytes, bearing surface IgM in blood, lymph nodes and spleen is closely connected with the progression of leukaemic process. An increased number of B-lymphocytes (2-3 times) with the receptors for complement was found. The proportion of T mu and T gamma cell subsets in CLL cows is distorted. The T gamma cell subset in T-cell suspensions from blood and spleen in CLL cows prevails in comparison with that in controls. The number of T mu cells in blood and lymph nodes in CLL is decreased.