Low-molecular weight nuclear RNA in the lymphocytes of healthy persons and chronic lympholeukemia patients
Blinov, M.N.; Vladimirova, A.D.; Luganova, I.S.
Voprosy Onkologii 24(5): 14-17
1978
ISSN/ISBN: 0507-3758 PMID: 664530 Document Number: 138867
Low-polymer nuclear RNA (1) of lymphocytes was studied comparatively in healthy individuals and patients with lympholeukemia. In 7.5% polyacrylamid gel both in normal lymphocytes and their leukemic analogs 9 fractions were identified which possess similar electrophoretic mobility. The correlation of separate fractions 1 in pathological lymphocytes was shown to differ from that in lymphocytes of healthy donors. The study of the metabolic activity 1 indicated that one of the fractions (D) is metabolically inert under conditions of a 1-hour label, while in normal lymphocytes one fraction was revealed, whereas in chronic lympholeukemia--two fractions being recorded only by their radioactivity.