Sulfonamide-associated keratoconjunctivitis sicca and corneal ulceration in a dysuric dog
Collins, B.K.; Moore, C.P.; Hagee, J.H.
Journal of the American Veterinary Medical Association 189(8): 924-926
1986
ISSN/ISBN: 0003-1488 PMID: 3490464 Document Number: 267890
Long-term sulfonamide (trimethoprim-sulfamethoxazole, 30 mg/kg, orally for 3 months) therapy for a urinary tract disorder affected the lacrimal gland causing dry eyes. Initial topical treatment of the ulcers may have potentiated the dry eye condition. The dog was referred with negligible tear production and bilateral corneal ulcers. Diagnostic evaluation of the urinary tract indicated reflex dyssynergia, a neurological disorder causing functional urinary tract obstruction. The combination of appropriate topical and surgical therapy of the eyes, discontinuation of sulfonamide treatment, and initiation of bethanechol in the treatment of reflex dyssynergia all contributed to return of a normal tear film. Any combination of systemic and/or topical therapy may affect lacrimal secretion.