Keratoconjunctivitis sicca in the dog associated with the administration of salicylazosulphapyridine (sulphasalazine)
Sansom, J.; Barnett, K.C.; Long, R.D.
Veterinary Record 116(15): 391-393
1985
ISSN/ISBN: 0042-4900 PMID: 2860750 Document Number: 267327
Thirteen cases of iatrogenic and bilateral keratoconjunctivitis sicca following the administration of the sulfonamide salicylazosulfapyridine (sulfasalazine) for the treatment of colitis were studied. No breed, age or sex incidence was noted in this series, unlike keratoconjunctivitis sicca cases due to other causes. The lacrimotoxic effect of sulfasalazine was permanent except in one case, and it is suggested that dogs on this drug should be monitored for tear secretion at regular intervals. Reports of a similar association between keratoconjunctivitis sicca and this drug and between the disease and other sulfonamides and compounds are discussed.