Stimulation of rat mastocytes and molecular oxygen
Lagneaux, D.; Lecomte, J.; Damas, J.
Archives Internationales de Physiologie et de Biochimie 94(5): S39-S42
1986
ISSN/ISBN: 0003-9799 PMID: 2440401 Document Number: 267675
Free peritoneal mast-cells of the rat are stimulated in vitro by molecular oxygen as well as by hydrogen peroxide. Histamine release is also observed in vivo when molecular oxygen or diluted solutions of hydrogen peroxide are injected into the peritoneal cavity of the rat. Inflammatory lesions are produced (vascular congestion, oedema, exudate) which are suppressed by pretreatment with anti-H1 antihistaminics. When hydrogen peroxide solutions are more concentrated, inflammation is also provoked but antihistaminics are no more inhibitory. Mast-cells of the skin and of the lungs are not stimulated neither by molecular oxygen, nor by hydrogen peroxide.