Treatment of arterial hypertension with nifedipine in patients with chronic renal insufficiency
Ambroso, G.C.; Como, G.; Scalamogna, A.; Citterio, A.; Casati, S.; Ponticelli, C.
Clinical Nephrology 23(1): 41-45
1985
ISSN/ISBN: 0301-0430 PMID: 3978881 Document Number: 267016
The acute and chronic antihypertensive effects of nifedipine were investigated in patients with chronic renal insufficiency (CRI). The acute effects were assessed after the administration either of a fast-release nifedipine capsule or a slow-release nifedipine tablet in 10 and 15 patients respectively. Both the preparations induced prompt and marked reduction of systolic and of diastolic blood pressure, but the capsules showed a shorter antihypertensive effect (2 hours) than tablets (more than 6 hours). The chronic effects of nifedipine tablets given in addition to the previous therapy was assessed in 25 patients with CRI and resistant hypertension. Both systolic and diastolic blood pressure values promptly fell and maintained within the normal range over the whole period of the study (12 months).