Early clinical experience with imipenem-cilistatin
Ellis-Pegler, R.B.; Downey, D.; Bremner, D.A.
New Zealand Medical Journal 98(775): 188-191
1985
ISSN/ISBN: 0028-8446 PMID: 3856762 Document Number: 265571
We treated 15 patients with 16 proven bacterial infections with imipenem-cilistatin. Nine isolates were gram positive cocci, the remaining ten being gram negative bacilli and all had MICs less than or equal to 2.0 mg/l. Eight patients had respiratory tract infections, four urinary tract infections and there were three others. Twelve of 16 infections were microbiologically cured. There were no important drug side effects or toxicity. Imipenem-cilistatin is a potentially useful formulation.
Document emailed within 1 workday
Related Documents
Igari, J. 1990: Susceptibilities of clinical bacterial isolates to antimicrobial agents. A study mainly focused on imipenem. Reported by the Research Group for Testing Imipenem Susceptibility on Clinical Isolates Japanese Journal of Antibiotics 43(11): 1956-2002Fujii, R.; Sakata, H.; Inyaku, F.; Fujita, K.; Maruyama, S.; Yoshioka, H.; Hashira, S.; Tajima, T.; Nakazawa, S.; Sato, H. 1989: Pharmacokinetic and clinical evaluation of imipenem/cilastatin sodium in neonates and premature infants. A study of imipenem/cilastatin sodium by a perinatal co-research group Japanese Journal of Antibiotics 42(4): 953-972
Oomomo, Y.; Maruhashi, T.; Hanaoka, J.; Minagawa, Y.; Yuzawa, H.; Tokunaga, A.; Takahashi, T.; Sasagawa, S.; Takeuchi, S. 1986: Clinical studies on the effect of imipenem/cilastatin sodium on infections in obstetrics and gynecology. Tissue concentrations and clinical effects Japanese Journal of Antibiotics 39(5): 1342-1349
Laczkovics, A.; Heidt, M.; Oelert, H.; Laufer, G.; Greve, H.; Pomar, J.L.; Mohr, F.W.; Haverich, A.; Birnbaum, D.; Regensburger, D.; Palatianos, G.; Wolner, E. 2001: Early clinical experience with the On-X prosthetic heart valve Journal of Heart Valve Disease 10(1): 94-99
Kirkman, R.L.; Shapiro, M.E.; Carpenter, C.B.; Milford, E.L.; Ramos, E.L.; Tilney, N.L.; Waldmann, T.A.; Zimmerman, C.E.; Strom, T.B. 1989: Early experience with anti-Tac in clinical renal transplantation Transplantation Proceedings 21(1 Part 2): 1766-1768
Chimura, T.; Morisaki, N.; Hirayama, T.; Matsuo, M. 1988: Clinical studies on imipenem/cilastatin sodium in perinatal use Japanese Journal of Antibiotics 41(11): 1751-1757
Lemieux, M.; Dumesnil, J.G.; Dowd, C.; Lutz, D.; Cartier, P.; Desaulniers, D.; Despres, J.P.; Metras, J.; Raymond, G. 1988: A new porcine bioprosthesis: design rationale and early clinical experience Canadian Journal of Cardiology 4(6): 322-327
Hawatmeh, A.S.; Walters, F.P.; Wooster, C.A. 1995: Early clinical experience with percutaneous cryosurgical ablation of the prostate Missouri Medicine 92(11): 705-709
Matsuda, S.; Suzuki, M.; Oh, K. 1988: Clinical studies on imipenem/cilastatin sodium in the perinatal period Japanese Journal of Antibiotics 41(11): 1774-1777
Nagata, K.; Yokoyama, M.; Ohnishi, A.; Izumi, Y. 1986: Clinical studies on imipenem/cilastatin sodium in pediatric field Japanese Journal of Antibiotics 39(7): 1708-1714
Taylor, C.; Lipsky, M.S.; Bauer, L. 1998: Focused teaching: facilitating early clinical experience in an office setting Family Medicine 30(8): 547-548
Chimura, T.; Morisaki, N.; Matsuo, M. 1986: Clinical studies on imipenem/cilastatin sodium in the field of obstetrics and gynecology Japanese Journal of Antibiotics 39(6): 1519-1525
Nakashima, T.; Nakashima, S.; Hayakawa, F.; Miyachi, Y.; Hakamada, S.; Kuno, K. 1986: Fundamental and clinical studies on imipenem/cilastatin sodium in the field of pediatrics Japanese Journal of Antibiotics 39(7): 1828-1846
Bégué, P.; Quinet, B.; Baron, S.; Challier, P.; Fontaine, J.L.; Lasfargues, G. 1989: Clinical and pharmacokinetic study of imipenem/cilastatin in children and newborn infants Pathologie-Biologie 37(5): 485-490
Konaga, E.; Takeuchi, H.; Orita, K.; Fuchimoto, S.; Ogawa, K.; Kitagawa, T.; Tokuda, N.; Kimura, H.; Hamada, F.; Nishiyama, Y. 1991: Clinical evaluation of intramuscular imipenem/cilastatin sodium in surgical infections Japanese Journal of Antibiotics 44(12): 1341-1350
Motohiro, T.; Koga, T.; Shimada, Y.; Tomita, S.; Fujimoto, T.; Nishiyama, T.; Tominaga, K.; Yamashita, F.; Suzuki, K.; Toyoda, O. 1986: Pharmacokinetic and clinical studies of imipenem/cilastatin sodium in the pediatric field Japanese Journal of Antibiotics 39(7): 1889-1911
Goldberg, V.M. 1993: Anatomic cementless total hip replacement: design considerations and early clinical experience Acta Orthopaedica Belgica 59(Suppl 1): 183-189
Jamieson, W.R.; Janusz, M.T.; Munro, A.I.; Miyagishima, R.T.; Tutassura, H.; Gerein, A.N.; Burr, L.H.; Allen, P. 1980: Early clinical experience with the carpentier-Edwards porcine heterograft cardiac valve Canadian Journal of Surgery. Journal Canadien de Chirurgie 23(2): 132-137
Matsuda, S.; Oh, K.; Tateno, M.; Kojima, Y.; Hirabayashi, K.; Okada, E.; Doko, F.; Kawai, J. 1991: Clinical study of intramuscular imipenem/cilastatin sodium in the field of obstetrics and gynecology Japanese Journal of Antibiotics 44(12): 1359-1367
Naito, H.; Hara, T.; Akagi, T.; Masaoka, T.; Kudo, Y.; Iwasaki, K.; Matsuo, M.; Urabe, T.; Fujiwara, A. 1986: Fundamental and clinical studies of imipenem/cilastatin sodium in the field of obstetrics and gynecology Japanese Journal of Antibiotics 39(5): 1401-1411