Cytotoxic T-lymphocyte recognition of simian virus 40 antigens
Tevethia, S.S.; Tevethia, M.J.
Cancer Surveys 4(1): 101-114
1985
ISSN/ISBN: 0261-2429 PMID: 3022921 Document Number: 265173
During the transformation of mammalian cells by SV40, the cells acquire new antigenicity at the cell surface that acts as a target for cytotoxic T lymphocytes. Evidence is discussed which leads to the conclusion that the product of the SV40 tsA gene, the T antigen, is directly involved in converting a cell to malignant phenotype, is largely localized in the nucleus of transformed cells and is also present at the cell surface. Therefore, it appears that the T antigen serves a dual function, i.e. it is involved in the initiation and maintenance of transformation and provides a target for the immune effector mechanisms in the host undergoing viral carcinogenesis.