MIs locus recognition by a cloned line of H-2-restricted influenza virus-specific cytotoxic T lymphocytes
Braciale, V.L.; Braciale, T.J.
Journal of Immunology 127(3): 859-862
1981
ISSN/ISBN: 0022-1767 PMID: 6455473 Document Number: 179605
The expression of strong MLs locus (MLsd) recognition was demonstrated in a cloned line of mouse H-2-restricted influenza virus-specific CTL [cytotoxic T lymphocytes]. This clone of F1 (H-2b/d; MLsb) origin specifically proliferated in response to uninfected cells of CBA/J (H-2k, MLsd) origin but not to uninfected B10.BR or CBA/CaJ cells (H-2k, MLsb). Proliferation by this CTL line was observed in response to histocompatible cells expressing cross-reactive MLsa determinants (DBA/2, NZB; H-2d, MLsa). This recognition was observed only at the level of CTL proliferation. The CTL line exhibited no cytotoxic activity for target cells of these Mls types. These observations are contrasted with the response of another cloned H-2-restricted influenza-specific TCL line that simultaneously exhibits alloreactivity for H-2k. The significance of these results for T lymphocyte recognition is discussed.