Changes in the immunological indices after splenectomy and the reimplantation of splenic fragments in an experiment
Durdyev, M.D.; Pashutin, S.B.; Belotskiĭ, S.M.
Biulleten' Eksperimental'noi Biologii i Meditsiny 99(6): 719-720
1985
ISSN/ISBN: 0365-9615 PMID: 4016264 Document Number: 264537
Splenectomized guinea-pigs underwent autotransplantation of splenic fragments into the greater omentum or mesentery of small intestine. Twenty-five to thirty days after operation the animals were infected with S. aureus and then were examined over time before and after infection at different times. Measurements were taken of T lymphocytes, B lymphocytes, lymphocytes with staphylococcal receptors, as well as of the content of neutrophils with IgG Fc-fragment and complement receptors. It was established that in guinea-pigs subjected to splenectomy followed by autotransplantation of decapsulated splenic fragments, the experimental generalized staphylococcal infection took a milder course, which was manifested by an increase in the above immunologic characteristics as compared to animals undergoing splenectomy alone.