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A pharmacokinetic study of antibiotics in patients with benign prostatic hypertrophy

Fujita, K.; Sayama, T.; Abe, S.; Murayama, T.; Sugimoto, M.; Hara, T.

Japanese Journal of Antibiotics 38(8): 2145-2148

1985

ISSN/ISBN: 0368-2781
PMID: 2416961
Document Number: 263977
Twenty cases intravenously received 1 g of cefotetan before the transurethral prostatectomy. High serum and prostatic concentrations were obtained and half-lives were 298 minutes for serum and 250 minutes for the prostate. The mean value of their creatinine clearance was as low as 46.6 ml/min and it was found to be the reason why the serum half-life time was longer than that reported for normal volunteers.

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