Prognostic and differentiating value of cellular nonspecific immune monitoring following kidney allotransplantation
Rasheva, M.; Stefanov, G.
Vutreshni Bolesti 24(4): 47-55
1985
ISSN/ISBN: 0506-2772 PMID: 3907145 Document Number: 263854
On the background of a brief literature survey, the effect of renal allotransplants on immune state was studied in 22 recipients during posttransplantation period. Non-specific immune monitoring was used in follow up the cellular immune reactivity to 2 types of cells--atypical mononuclears (ATM) and spontaneous blast-transformed lymphocytes (SBT/Ly). It was established that the appearance and increase of ATM in peripheral blood could serve the prognosis of one crisis in rejecting the allotransplant, and SBT/Ly, is accepted as a sign for concomitant infection or originating in the course of immunosuppressive therapy. The differentiation of those two types of cells is of significance for the early diagnosis of the crises for rejection and aid the proper treatment of the patients with renal allotransplantation.