Genetic problems of hereditary polyposis of the large intestine. I. An analysis of the interrelation with intestinal cancer
Al'tshuler, B.A.; Nikitin, A.M.; Bazhenova, M.D.; Tatishvili, G.G.
Genetika 21(8): 1380-1386
1985
ISSN/ISBN: 0016-6758 PMID: 3902567 Document Number: 263774
An attempt has been made to estimate the correlation of oncological illnesses in the families within the limits of segregational and correlational analyses, considering the fact of accumulation in the families of probands with autosomal-dominant polyposes of colon of the cases of primary (without preceding polyposes) colon cancer. Significant correlation was found between the hereditary polyposes and primary colon cancer in the families studied. Based on these data, a hypothesis is discussed of the main gene and its modifications on the phenotypical version in the form of primary benign (polyposes) and malignant (cancer) pathology. No significant correlation was found between colon polyposes and cancer of stomach in the families.