Efficacy of single- versus multiple-dose clotrimazole therapy in the management of vulvovaginal candidiasis
Lebherz, T.; Guess, E.; Wolfson, N.
American Journal of Obstetrics and Gynecology 152(7 Pt 2): 965-968
1985
ISSN/ISBN: 0002-9378 PMID: 3895962 Document Number: 263282
Single-dose treatment of vulvovaginal Candida infection with a 500 mg clotrimazole vaginal tablet was compared with 3-day treatment with two 100 mg vaginal tablets administered daily in 115 patients enrolled in a double-blind trial, 101 of whom were evaluated for efficacy. Patients with clinically and mycologically active disease were treated (visit 1) and examined at 5-10 days (visit 2) and again at least 27 days (visit 3) post treatment. At visit 2, mycological tests and clinical examinations were negative in 37 of 48 patients receiving single-dose treatment (77%) and in 47 of 53 patients receiving 3-day treatment (89%). Corresponding results for visit 3 were 65 and 74%, respectively. There were no significant differences in treatment response between groups, and only 3 patients reported adverse reactions.