Initial ultrastructural changes in the muscle fibers of the diaphragm in rats exposed to chlorophos
Kuznetsov, V.G.; Tomilin, N.V.; Cherniak, T.F.; Mashanskiĭ, V.F.
Tsitologiia 27(4): 411-414
1985
ISSN/ISBN: 0041-3771 PMID: 4002340 Document Number: 262159
Ultrastructural changes of rat diaphragm muscle fibers were studied after administration of chlorophos, i. e. organophosphorus inhibitor. Observations were made 10-180 seconds after treatment (concentrations--18 and 24 mM). The swelling of mitochondria and the increase in the length of sarcomeres were observed simultaneously. These changes were phasic. The swelling of mitochondria is probably due to the increase in energetical activity of muscle fibres.