HLA-DR-dependent variation of intrathecal IgG1 (Gm) allotype synthesis in multiple sclerosis
Salier, J.P.; Martin-Mondiere, C.; Sesboüé, R.; Daveau, M.; Goust, J.M.; Govaerts, A.; Schuller, E.; Degos, J.D.
Journal of Immunology 134(3): 1551-1554
1985
ISSN/ISBN: 0022-1767 PMID: 3855432 Document Number: 260907
Genetic susceptibility to multiple sclerosis (MS) in Caucasians was previously shown to be correlated to the presence of given alleles at the HLA-DR and Gm loci. We now demonstrate that the humoral immune response in MS central nervous system (CNS) is modulated by both loci: the levels of IgG1 subclass and IgG1 allotypes in cerebrospinal fluid of MS patients depend on both their Gm genotype and their HLA-DR2 or HLA-DR7 phenotype. That HLA-DR molecules may either participate in a preferential recruitment of IgG1 allotype-producing B cells in MS CNS or act after such a selective homing is discussed. These results demonstrate that both HLA and Gm loci are synergistically involved in the modulation of the humoral immune response.