Intrathecal methylprednisolone acetate in multiple sclerosis treatment. Clinical evaluation
Mazzarello, P.; Poloni, M.; Piccolo, G.; Cosi, V.; Pinelli, P.
Acta Neurologica Belgica 83(4): 190-196
1983
ISSN/ISBN: 0300-9009 PMID: 6689244 Document Number: 219882
Twenty-eight patients with clinically definite Multiple Sclerosis were treated with intrathecal injections of Methylprednisolone acetate, 40 mg at four days intervals. Kurtzke's Disability Status Scale was evaluated in all the patients together with sum of scores for the neurological functions and the subjective assessment, before and after the treatment. Ten Multiple Sclerosis patients, treated with prednisone (100 mg at alternate days) were taken as a control group. No real advantages were found with the intrathecal treatment as compared to the orally administered steroids.
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