Suppositories containing cyclodextrin complexes. Part 2: Dissolution and absorption studies
Szente, L.; Apostol, I.; Gerlóczy, A.; Szejtli, J.
Die Pharmazie 40(6): 406-407
1985
ISSN/ISBN: 0031-7144 PMID: 4034649 Document Number: 260340
The dissolution and absorption of poorly water-soluble drugs from rectal suppositories can be enhanced by complexing these substances (e.g., essential oils, indomethacin) with .beta.-cyclodextrin. Preliminary in vivo studies showed, that the application of cyclodextrin complexes to suppositories, the same as to oral applications, resulted in an increased blood level.
Document emailed within 1 workday
Related Documents
Horváth, G.; Nagy, K. 1994: Comparative in vitro dissolution studies of piroxicam suppositories using the basket, the paddle and the flow through methods Acta Pharmaceutica Hungarica 64(4): 135-140Kaulpiboon, J.; Rudeekulthamrong, P. 2010: Effect of temperature on cyclodextrin production and characterization of paracetamol/cyclodextrin complexes Journal of the Medical Association of Thailand 93(Suppl 6): S160-S165
Ammar, H.O.; Khalil, R.M. 1996: Discrepancy among dissolution rates of commercial tablets as a function of dissolution method. part 6: rifampicin Die Pharmazie 51(3): 165-168
Alighieri, T.; Avanessian, S.; Berlini, S.; Bianchi, S.G.; Deluigi, P.; Valducci, R.; Guelen, P.J. 1988: Bioavailability of ambroxol sustained release preparations. Part I: In vitro dissolution studies Arzneimittel-Forschung 38(1): 92-94
Tencova, A.; Kiszeleva, G.; Selmeczi, B.; Kedvessy, G.; Nagy, G. 1984: Technological processes and the influence of adjuvants on the dissolution rate and absorption of some ingredients from tablets. V. Release and absorption capacity of sulfadimidine Acta Pharmaceutica Hungarica 54(6): 245-248
Huynh-Ngoc, T.; Sirois, G. 1976: Evaluation of the continuous fluid exchange system in the USP basket-stirrer dissolution test assembly. Part I: pH-dissolution rate behavior Journal de Pharmacie de Belgique 58(6): 589-598
Bećirević-Laćan, M.; Filipović-Grcić, J. 2000: Effect of hydroxypropyl-beta-cyclodextrin on hydrocortisone dissolution from films intended for ocular drug delivery Die Pharmazie 55(7): 518-520
Huynh-Ngoc, T.; Sirois Gérard 1977: Evaluation of a continuous fluid exchange system in the USP basket-stirrer dissolution test assembly. Part 11: Characterization of the dissolution profile of quinidine sustained-release dosage forms Journal de Pharmacie de Belgique 32(1): 67-75
Selmeczi, B.; Kedvessy, G.; Nagy, G.; Pintyéné Hódi, K.; Tencova, A.; Kiszeleva, G. 1981: Influence of the technological procedure and additives on the dissolution rate and absorption of active ingredients. I. Physical properties of acetylsalicylic acid tablets and of the dissolution rate of the active ingredient Acta Pharmaceutica Hungarica 51(5): 222-227
Kvan, L. 1971: Absorption of phenytoin suppositories Nordisk Medicin 86(48): 1438
Heppt-Becker, I.; Schunack, W. 1976: Absorption studies with purines. Part 2. in vitro experiments with a diffusion apparatus Arzneimittel-Forschung 26(4): 473-476
Fraceto, L.Fernandes.; Grillo, R.; Sobarzo-Sánchez, E. 2014: Cyclodextrin inclusion complexes loaded in particles as drug carrier systems Current Topics in Medicinal Chemistry 14(4): 518-525
Nagarsenker, M.S.; Meshram, R.N.; Ramprakash, G. 2000: Solid dispersion of hydroxypropyl beta-cyclodextrin and ketorolac: enhancement of in-vitro dissolution rates, improvement in anti-inflammatory activity and reduction in ulcerogenicity in rats Journal of Pharmacy and Pharmacology 52(8): 949-956
Axelsson, C.K.; Otkjaer, S.; Andersen, S.T.; Arnold, E. 1985: Absorption of metronidazole suppositories in patients with postoperative ileus Danish Medical Bulletin 32(2): 134-137
Tanaka, M.; Iwata, Y.; Kouzuki, Y.; Taniguchi, K.; Matsuda, H.; Arima, H.; Tsuchiya, S. 1995: Effect of 2-hydroxypropyl-beta-cyclodextrin on percutaneous absorption of methyl paraben Journal of Pharmacy and Pharmacology 47(11): 897-900
Vollmer, U.; Müller, B.W.; Peeters, J.; Mesens, J.; Wilffert, B.; Peters, T. 1994: A study of the percutaneous absorption-enhancing effects of cyclodextrin derivatives in rats Journal of Pharmacy and Pharmacology 46(1): 19-22
Gerlóczy, A.; Fónagy, A.; Keresztes, P.; Perlaky, L.; Szejtli, J. 1985: Absorption, distribution, excretion and metabolism of orally administered 14C-beta-cyclodextrin in rat Arzneimittel-Forschung 35(7): 1042-1047
Noseda, G.; Fragiacomo, C.; Peruzzi, M.; Cremonesi, P.; Chinea, B. 1988: Comparative absorption kinetics of imidazole and salicylic acid in volunteers after administration of ITF 182 tablets and suppositories International Journal of Clinical Pharmacology Research 8(3): 169-173
Ozyazici, M.; Gökçe, E.; Hizarcioglu, S.Y.; Taner, M.S.; Köseoglu, K.; Ertan, G. 2006: Dissolution and vaginal absorption characteristics of metronidazole and ornidazole Die Pharmazie 61(10): 855-861
Xie Xian-yun 1979: The dissolution rate and absorption of nithiocyamine solid dispersion Yao Xue Xue Bao 14(1): 45-48