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Comparative absorption kinetics of imidazole and salicylic acid in volunteers after administration of ITF 182 tablets and suppositories

Noseda, G.; Fragiacomo, C.; Peruzzi, M.; Cremonesi, P.; Chinea, B.

International Journal of Clinical Pharmacology Research 8(3): 169-173

1988

ISSN/ISBN: 0251-1649
PMID: 3403104
Document Number: 318387
Comparative absorption kinetics in volunteers of a new antinflammatory drug (Selezen), in the form of 750 mg tablets and suppositories, were studied. The two components of the drug, imidazole and salicyclic acid were found in plasma. Pharmacokinetic parameters were calculated according to a first order absorption. Salicylic acid showed a maximum concentration 59.2 .+-. 5 min and 75.4 .+-. 7.6 min after the administration of the tablet and suppository respectively; and imidazole after 86.3 .+-. 10.8 min and 75.2 .+-. 5.4 min, respectively.

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