Cefoperazone: microbiological, kinetic and clinical studies
Di Nola, F.; Soranzo, M.L.; Capra, E.; Eandi, M.; Salassa, B.; Arione, R.; Cimino, T.; Grosa, M.; Chiavarino, M.; Bramato, C.
Minerva Medica 76(39): 1795-1801
1985
ISSN/ISBN: 0026-4806 PMID: 4047462 Document Number: 260060
In vitro cefoperazone proved more active against the tested gram-negative bacteria than either piperacillin or mezlocillin. When administered in 1 g venous bolus the antibiotic achieved high plasmatic concentrations that were still adequate after 8 hours. 33.2% was excreted by the kidneys and a considerable amount by the biliary way. Cefoperazone produced a clinical cure in 35/36 patients (97.22%). A disulfiram-like effect was noted in 18.18%.