Bioavailability studies of calcium dobesilate--a case of flip-flop kinetics
Franke, G.; Schneider, T.; Siegmund, W.; Scherber, A.
Die Pharmazie 40(8): 562-563
1985
ISSN/ISBN: 0031-7144 PMID: 4080804 Document Number: 257918
Absolute and relative bioavailability of two commercial calcium dobesilate tablets were evaluated in ten healthy volunteers in a cross-over trial using a newly developed HPLC detection method. Both tablet forms were absorbed completely but very slowly thus leading to a flip-flop kinetics. It could be shown that AUC values derived from flip-flop models were comparable with those of normal i. v. kinetics.