Kinetics of early time calcium oxalate nephrolithiasis
Jordan, W.R.; Finlayson, B.; Luxenberg, M.
Investigative Urology 15(6): 465-468
1978
ISSN/ISBN: 0021-0005 PMID: 649295 Document Number: 133751
This paper examines the kinetics of calcium deposition in rat kidneys after an intraperitoneal sodium oxalate injection. From the results we conclude that only a limited portion of tubular surface is available for adsorption of calcium oxalate crystals, that adsorpption of calcium oxalate crystals onto tubular epithelium is a process of greater than first order with regard to the dose, and that the washout of retained particles from the tubules is a first-order process as related to time. Also, we conclude that in these animals, which were subjected to a large oxalate challenge, the deposition of calcium oxalate crystals is virtually all intratubular.