Investigation of possible polymorphic drug oxidation in black South Africans
Skene, D.J.; Modipane, A.; Joubert, P.H.
South African Medical Journal 68(9): 653-654
1985
ISSN/ISBN: 0256-9574 PMID: 4060024 Document Number: 257853
The ability to oxidize phenacetin into paracetamol was investigated in 117 healthy South African black subjects. Statistical analysis of the amount of paracetamol excreted in the 0-8-hour urine sample revealed a normal distribution (P less than 0,05). There was thus no evidence of polymorphism; the subjects appeared to be exclusively monomorphic extensive metabolizers.
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