The thrombotic profile of treatment-naive HIV-positive Black South Africans with acute coronary syndromes
Becker, A.C.; Jacobson, B.; Singh, S.; Sliwa, K.; Stewart, S.; Libhaber, E.; Essop, M.R.
Clinical and Applied Thrombosis/Hemostasis Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 17(3): 264-272
2011
ISSN/ISBN: 1938-2723 PMID: 20460356 DOI: 10.1177/1076029609358883Document Number: 218897
Patients with human immunodeficiency virus (HIV) infection on protease inhibitors (PIs) have a heightened risk of arterial thrombosis but little is known about treatment-naive patients. Prospective study from South Africa comparing thrombotic profiles of HIV-positive and -negative patients with acute coronary syndrome (ACS). A total of 30 treatment-naive HIV-positive patients with ACS were compared to 30 HIV-negative patients with ACS. Patients with HIV were younger; and besides smoking (73% vs 33%) and low high-density lipoprotein (HDL; 0.8 ± 0.3 vs 1.1 ± 0.4), they had fewer risk factors. Thrombophilia was more common in HIV-positive patients with lower protein C (PC; 82 ± 22 vs 108 ± 20) and higher factor VIII levels (201 ± 87 vs 136 ± 45). Patients with HIV had higher frequencies of anticardiolipin (aCL; 47% vs 10%) and antiprothrombin antibodies (87% vs 21%). Treatment-naive HIV-positive patients with ACS are younger, with fewer traditional risk factors but a greater degree of thrombophilia compared with HIV-negative patients.